Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication.

@article{Mullin2004IncreasedAO,
  title={Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication.},
  author={Anne E. Mullin and Rosa Maria Dalton and Maria Jo{\~a}o Amorim and Debra Elton and Paul Digard},
  journal={The Journal of general virology},
  year={2004},
  volume={85 Pt 12},
  pages={3689-98}
}
Influenza virus genome replication requires the virus-encoded nucleoprotein (NP), partly because it is necessary to encapsidate the viral genomic RNA (vRNA) and antigenomic cRNA segments into ribonucleoproteins (RNPs). However, there is also evidence that NP actively regulates viral RNA synthesis and there is a long-standing hypothesis that increased concentrations of NP in the cell are responsible for a switch from genome transcription to replication. Here, this hypothesis is tested in a… CONTINUE READING

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