Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.

@article{Doorn2014IncreasedAM,
  title={Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.},
  author={Karlijn J. Doorn and Andrea Goudriaan and Carla Blits-Huizinga and John G. J. M. Bol and Annemieke J. M. Rozemuller and Piet V J M Hoogland and Paul John Lucassen and Benjamin Drukarch and Wilma D. J. van de Berg and Anne-Marie van dam},
  journal={Brain pathology},
  year={2014},
  volume={24 2},
  pages={152-65}
}
The olfactory bulb (OB) is affected early in both Parkinson's (PD) and Alzheimer's disease (AD), evidenced by the presence of disease-specific protein aggregates and an early loss of olfaction. Whereas previous studies showed amoeboid microglia in the classically affected brain regions of PD and AD patients, little was known about such changes in the OB. Using a morphometric approach, a significant increase in amoeboid microglia density within the anterior olfactory nucleus (AON) of AD and PD… CONTINUE READING
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