Increased airway pressure in response to xylazine is inhibited by both atipamezole and atropine in sheep.

@article{Papazoglou1994IncreasedAP,
  title={Increased airway pressure in response to xylazine is inhibited by both atipamezole and atropine in sheep.},
  author={Lysimachos G. Papazoglou and Dimitris G. Raptopoulos and Nikolaos A Kokolis},
  journal={Zentralblatt fur Veterinarmedizin. Reihe A},
  year={1994},
  volume={41 7},
  pages={568-72}
}
The effect on airway pressure of xylazine alone or following the administration of atipamezole or atropine was studied in 31 halothane-anaesthetized sheep. Xylazine produced a significant increase in airway pressure which lasted for at least 30 min. This effect was inhibited by both atipamezole and atropine. The results suggest that the xylazine-induced increase in airway pressure in sheep is alpha 2-adrenergically mediated. Moreover, activation of central alpha 2-adrenoceptors leading to vagal… CONTINUE READING

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