Increased affinity predominates in insulin stimulation of glucose transport in the adipocyte.

Abstract

The kinetics for transport of glucose and 3-O-methylglucose (MeGlc) were determined in preparations of rat adipocytes characterized by low basal rates which could be increased consistently more than 30-fold by addition of insulin (10 nM). In basal cells, the Km of [14C]glucose uptake was about 75 mM. The Ki for glucose inhibition of [14C]MeGlc uptake was… (More)

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