Increased adrenal sensitivity to angiotensin II in idiopathic hyperaldosteronism.

  title={Increased adrenal sensitivity to angiotensin II in idiopathic hyperaldosteronism.},
  author={M Wisgerhof and Paul C. Carpenter and Russell D. Brown},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={47 5},
Plasma aldosterone increases briskly during upright posture in patients with idiopathic hyperaldosteronism, despite only small increases in PRA and presumably small increases in angiotensin II. To examine the postulate that small increments in angiotensin II mediate these brisk increases in aldosterone, we infused graded doses of angiotensin II into normal subjects and patients with idiopathic hyperaldosteronism and compared the changes in levels of plasma aldosterone in the two groups… CONTINUE READING


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