Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

@article{Hotamisligil1995IncreasedAT,
  title={Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.},
  author={G{\^o}khan S. Hotamisligil and Peter Arner and Jos{\'e} F. Caro and Richard L. Atkinson and Bruce M Spiegelman},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 5},
  pages={
          2409-15
        }
}
Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. However, the mechanisms linking obesity to insulin resistance and diabetes in humans remain largely unknown. In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese… 

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