Increased adhesion of the promyelocytic leukaemia cell line, NB4, to fibronectin and thrombospondin upon all‐trans‐retinoic acid treatment

@article{Touhami1999IncreasedAO,
  title={Increased adhesion of the promyelocytic leukaemia cell line, NB4, to fibronectin and thrombospondin upon all‐trans‐retinoic acid treatment},
  author={Mohamed Ebn Touhami and J F Bourge and Chantal Legrand},
  journal={British Journal of Haematology},
  year={1999},
  volume={104}
}
We have evaluated the effects of all‐trans‐retinoic acid (RA) on the adhesion of the human promyelocytic cell line NB4 to various components of the extracellular matrix. NB4 cells, radiolabelled with 111Indium, showed a 2–3‐fold increase (P < 0.001) in adhesion to fibronectin and thrombospondi‘n upon RA (3 × 10−7 m) treatment, whereas adhesion to collagen I, laminin and vitronectin was not modified. The increase in cell adhesion, observed as early as day 1, preceded cell differentiation and was… 
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Ciblage de cellules leucemiques
La presente invention concerne le ciblage d'une molecule sur une cellule leucemique, que l'on effectue en mettant d'abord en contact la cellule avec un retinoide dans une quantite efficace pour
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