Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias.

@article{Calon2004IncreasedAA,
  title={Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias.},
  author={Fr{\'e}d{\'e}ric Calon and Mehdi Dridi and Oleh Hornykiewicz and Paul J. B{\'e}dard and Ali H. Rajput and Th{\'e}r{\`e}se Di Paolo},
  journal={Brain : a journal of neurology},
  year={2004},
  volume={127 Pt 5},
  pages={1075-84}
}
Brain adenosine A2A receptors have recently attracted considerable attention because of their interaction with the dopaminergic system and as potential targets for Parkinson's disease pharmacotherapy. Post mortem adenosine A2A receptor mRNA and [3H]SCH 58261- specific binding to adenosine A2A receptor were studied in the brain of Parkinson's disease patients using in situ hybridization and receptor binding autoradiography, respectively. Fourteen levodopa-treated Parkinson's disease patients, of… CONTINUE READING

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Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys

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