Increased activity of vascular ACE related to atherosclerotic lesions in hyperlipidemic rabbits.

@article{Mitani1996IncreasedAO,
  title={Increased activity of vascular ACE related to atherosclerotic lesions in hyperlipidemic rabbits.},
  author={Hironobu Mitani and Toshio Bandoh and Masaaki Kimura and Teruharu Totsuka and Shun-suke Hayashi},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 2},
  pages={
          H1065-71
        }
}
The relationship between vascular angiotensin-converting enzyme (ACE) activity in the aorta and atherosclerotic lesions was investigated in rabbits fed two atherogenic diets, 0.5 and 1.5% cholesterol, for 17 wk. Tissue ACE activity was assessed by the cleavage rate of hippuric acid from a synthetic substrate. Total cholesterol, triglycerides, and phospholipids in the serum were significantly increased by the diet. Vascular ACE activity in the femoral artery, abdominal aorta, and aortic arch was… CONTINUE READING
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