Increased activity of guanosine 3'-5'-cyclic monophosphate phosphodiesterase in the renal tissue of cirrhotic rats with ascites.

@article{Angeli2000IncreasedAO,
  title={Increased activity of guanosine 3'-5'-cyclic monophosphate phosphodiesterase in the renal tissue of cirrhotic rats with ascites.},
  author={Paolo Angeli and Wladimiro Jim{\'e}nez and R Veggian and Silvano Fasolato and Roberta Volpin and H S MacHenzie and R Craighero and V D Libera and Antonietta Sticca and Vicente Arroyo and Angelo Gatta},
  journal={Hepatology},
  year={2000},
  volume={31 2},
  pages={304-10}
}
A possible defect of guanosine 3'-5'-cyclic monophosphate (cGMP) content in the renal tissue caused by an increased activity of cGMP phosphodiesterase (PDE) has, so far, not been evaluated in the pathogenesis of renal resistance to endogenous natriuretic peptides (ENP) in cirrhosis with ascites. To test this hypothesis the activity of cGMP-PDE and the concentration of cGMP were evaluated in vitro in the renal tissue of 10 control rats and 10 cirrhotic rats with ascites before and after the… CONTINUE READING

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