Increased activity of certain hepatic drug-metabolizing enzymes due to subchronic exposure to bromobenzene.

@article{Chakrabarti1984IncreasedAO,
  title={Increased activity of certain hepatic drug-metabolizing enzymes due to subchronic exposure to bromobenzene.},
  author={Sudipta Chakrabarti},
  journal={Toxicology letters},
  year={1984},
  volume={20 1},
  pages={79-83}
}
Male Sprague-Dawley rats were treated i.p. with different doses of bromobenzene (0, 0.1, 0.2, 0.3 and 0.5 mmol/kg) in corn oil for 4 weeks. The animals were killed 24 h after the end of the treatment for hepatic drug metabolism studies. A significant induction of the activities of microsomal aniline hydroxylase (51%) and aminopyrine N-demethylase (58%) was observed at 0.5 mmol/kg dose level. Liver microsomal cytochrome P-450 content was significantly increased (approx. 38%) at subchronic doses… CONTINUE READING

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