Increased activity of Rho kinase contributes to hemoglobin-induced early disruption of the blood-brain barrier in vivo after the occurrence of intracerebral hemorrhage.

@article{Fu2014IncreasedAO,
  title={Increased activity of Rho kinase contributes to hemoglobin-induced early disruption of the blood-brain barrier in vivo after the occurrence of intracerebral hemorrhage.},
  author={Zhenghao Fu and Yizhao Chen and Fengzhen Qin and Shuo Yang and Xinqing Deng and Rui Ding and Liang Feng and Weiguang Li and Jianfeng Zhu},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 11},
  pages={7844-53}
}
This study is to examine whether the activation of Rho kinase (ROCK) accounts for hemoglobin (Hb)-induced disruption of blood-brain barrier (BBB) after the occurrence of intracerebral hemorrhage. A model of intracerebral injection of Hb was established in rats. Changes in the levels of mRNA of RhoA, ROCK2 and matrix metalloproteinase-9 (MMP-9) were measured using quantitative real-time polymerase chain reaction. Protein expression of RhoA, ROCK2, claudin-5 and MMP-9, as well as ROCK activity… CONTINUE READING
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