Increased activities of thymidine kinase isozymes in human mammary tumours

@article{Sakamoto1986IncreasedAO,
  title={Increased activities of thymidine kinase isozymes in human mammary tumours},
  author={Shinobu Sakamoto and Takeo Iwama and Masakazu Ebuchi and Kunio Tsukada and T Sagara and T. Kawasaki and Saburo Murakami and Noriyuki Kasahara and Hideki Kudo and Ryohei Okamoto},
  journal={British Journal of Surgery},
  year={1986},
  volume={73}
}
Thymidine kinase, the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 10 specimens of normal mammary gland, 10 fibroadenomas and 11 adenocarcinomas in human breasts. The average thymidine kinase activities in fibroadenomas and adenocarcinomas were about 3 and 8 times that in normal mammary gland. The mammary thymidine kinase isozymes were separated into two types by diethylaminoethyl (DEAE) cellulose column chromatography. The activity of the thymidine kinase isozyme… 

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TLDR
The results suggest that increases in the activities in the former and latter TK isozymes may indicate tumorigenesis and carcinogenesis, respectively, in the human colon.

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TLDR
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TLDR
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