Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat.

@article{Naliboff2008IncreasedAS,
  title={Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat.},
  author={Bruce D. Naliboff and Allison M Waters and Jennifer S. Labus and Lisa A Kilpatrick and Michelle G Craske and Lin Chang and Hideki Negoro and Hana Ibrahimovic and Emeran A. Mayer and Edward M. Ornitz},
  journal={Psychosomatic medicine},
  year={2008},
  volume={70 8},
  pages={920-7}
}
BACKGROUND AND AIMS Visceral hypersensitivity and symptom severity in Irritable Bowel Syndrome (IBS) are both exacerbated by stress. The eye-blink startle response represents a noninvasive measure of central defensive responding. Evidence for central hyperexcitability was studied in IBS patients by examining potentiation of the startle reflex to a nociceptive threat. METHODS Acoustic startle responses were examined in female IBS patients (n = 42) and healthy controls (n = 22) during cued… CONTINUE READING

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