Increased acid resistance of the archaeon, Metallosphaera sedula by adaptive laboratory evolution

  title={Increased acid resistance of the archaeon, Metallosphaera sedula by adaptive laboratory evolution},
  author={Chenbing Ai and Samuel McCarthy and Valerie Eckrich and D. Rudrappa and G. Qiu and P. Blum},
  journal={Journal of Industrial Microbiology & Biotechnology},
  • Chenbing Ai, Samuel McCarthy, +3 authors P. Blum
  • Published 2016
  • Biology, Medicine
  • Journal of Industrial Microbiology & Biotechnology
  • Extremely thermoacidophilic members of the Archaea such as the lithoautotroph, Metallosphaera sedula, are among the most acid resistant forms of life and are of great relevance in bioleaching. Here, adaptive laboratory evolution was used to enhance the acid resistance of this organism while genomics and transcriptomics were used in an effort to understand the molecular basis for this trait. Unlike the parental strain, the evolved derivative, M. sedula SARC-M1, grew well at pH of 0.90. Enargite… CONTINUE READING
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