Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.

@article{Timmons1996IncreasedAG,
  title={Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.},
  author={J. Timmons and S. Poucher and D. Constantin-Teodosiu and V. Worrall and I. Macdonald and P. Greenhaff},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 3},
  pages={
          879-83
        }
}
Skeletal muscle contractile function is impaired during acute ischemia such as that experienced by peripheral vascular disease patients. We therefore, examined the effects of dichloroacetate, which can alter resting metabolism, on canine gracilis muscle contractile function during constant flow ischemia. Pretreatment with dichloroacetate increased resting pyruvate dehydrogenase complex activity and resting acetylcarnitine concentration by approximately 4- and approximately 10-fold, respectively… Expand
89 Citations
Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise.
  • 94
  • PDF
Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise.
  • 140
  • PDF
Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics.
  • 4
Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction.
  • PDF
Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction.
  • 9
Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise.
  • PDF
Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
  • 18
Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle.
  • 21
  • PDF
The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle
  • 33
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
PDC activity and acetyl group accumulation in skeletal muscle during isometric contraction.
  • 34
Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans.
  • 59
  • Highly Influential
Pyruvate dehydrogenase influences postischemic heart function.
  • 127
Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts.
  • 199
Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise.
  • 161
A delivery-independent blood flow effect on skeletal muscle fatigue.
  • J. Barclay
  • Chemistry, Medicine
  • Journal of applied physiology
  • 1986
  • 72
Increased [lactate] in working dog muscle reduces tension development independent of pH.
  • 118
Regulation of pyruvate dehydrogenase complex in ischemic rat heart.
  • 66
  • Highly Influential
Substrate exchange in human limb muscle during exercise at reduced blood flow.
  • 25
Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling.
  • 144
  • Highly Influential
...
1
2
3
4
...