Increased accumulation of the glycoxidation product Nepsilon-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody.

@article{Schalkwijk2004IncreasedAO,
  title={Increased accumulation of the glycoxidation product Nepsilon-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody.},
  author={Casper G Schalkwijk and Alexi Baidoshvili and Coen D A Stehouwer and Victor W. M. van Hinsbergh and Hans W. M. Niessen},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1636 2-3},
  pages={
          82-9
        }
}
Heart failure is a condition closely linked to diabetes. Hyperglycaemia amplifies the generation of a major advanced glycation end product Nepsilon-(carboxymethyl)lysine (CML), which has been associated with the development of vascular and inflammatory complications. An increased accumulation of CML in hearts of diabetic patients may be one of the mechanisms related to the high risk of heart failure. Therefore, we investigated the localization of CML in diabetic hearts. To investigate the… CONTINUE READING

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