Increased accumulation of oxytocin messenger ribonucleic acid in the hypothalamus of the female rat: induction by long term estradiol and progesterone administration and subsequent progesterone withdrawal.

@article{Crowley1995IncreasedAO,
  title={Increased accumulation of oxytocin messenger ribonucleic acid in the hypothalamus of the female rat: induction by long term estradiol and progesterone administration and subsequent progesterone withdrawal.},
  author={Roxane Crowley and Thomas R. Insel and Joan A. O'keefe and Nancy M. Amato O. Burchan Bayazit Kyunghwan Kim and Janet A. Amico},
  journal={Endocrinology},
  year={1995},
  volume={136 1},
  pages={224-31}
}
To examine a possible role for gonadal steroid hormones in the enhanced accumulation of hypothalamic oxytocin (OT) messenger RNA (mRNA) and peptide in late pregnancy, we used an established model (22) in which sequential administration of estradiol (E2) and progesterone (P) SILASTIC capsules to ovariectomized rats is followed by removal of P. Long term and sustained E2 combined with abrupt P withdrawal mimics the gonadal steroid hormone pattern of late gestation in the rat (22). Using this… CONTINUE READING

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