Increased accessibility of the N-terminus of testis-specific histone TH2B to antibodies in elongating spermatids.

@article{Unni1995IncreasedAO,
  title={Increased accessibility of the N-terminus of testis-specific histone TH2B to antibodies in elongating spermatids.},
  author={Emmanual Unni and Artur Mayerhofer and Yingjia Zhang and Yogendra M. Bhatnagar and Lonnie Dee Russell and Marvin Lawrence Meistrich},
  journal={Molecular reproduction and development},
  year={1995},
  volume={42 2},
  pages={
          210-9
        }
}
Changes in chromatin structure during spermatogenesis were investigated using a monoclonal antibody that immunoreacts with the N-terminus of the testis-specific histone TH2B. This monoclonal antibody, which had been raised against rat tyrosine hydroxylase (TH), cross-reacted with TH2B because of sequence homology at the N-termini of TH and TH2B. The epitope was localized to the N-terminus of TH2B as trypsin-digested chromatin which lacked the N-terminal tail did not react with anti-TH and… CONTINUE READING
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