Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients

@inproceedings{Topol2015IncreasedAO,
  title={Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients},
  author={Aaron B. Topol and Jane A. English and Ellen Flaherty and Prashanth Rajarajan and Brigham J. Hartley and Sanjeev Gupta and Fiona A. Desland and Shijia Zhu and Tami Goff and Lawrence Friedman and Judith L. Rapoport and Dan Felsenfeld and Gerard Cagney and Alan Mackay-Sim and Jeffrey N Savas and Bruce J. Aronow and Gang Fang and Bei Zhang and David Richard Cotter and Kristen J Brennand},
  booktitle={Translational Psychiatry},
  year={2015}
}
The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly… CONTINUE READING
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Analysis of copy number variations at 15 schizophrenia-associated loci

The British journal of psychiatry : the journal of mental science • 2014

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