Increased VO2 max with right-shifted Hb-O2 dissociation curve at a constant O2 delivery in dog muscle in situ.

@article{Richardson1998IncreasedVM,
  title={Increased VO2 max with right-shifted Hb-O2 dissociation curve at a constant O2 delivery in dog muscle in situ.},
  author={Russell Richardson and Koyye Ravindranath Tagore and Luke J. Haseler and Milan Jordan and Peter D. Wagner},
  journal={Journal of applied physiology},
  year={1998},
  volume={84 3},
  pages={995-1002}
}
If the diffusive component of O2 transport in muscle is important in determining exercise capacity, an increased capillary-to-tissue PO2 difference should enhance gas exchange from blood to skeletal muscle during exercise. Thus a rightward shift in the O2 dissociation curve should theoretically increase O2 extraction and improve maximal O2 uptake (VO2 max). To test this hypothesis, we used the canine gastrocnemius muscle to study maximal exercise in eight dogs at a normal P50 (33.1 +/- 0.4 Torr… CONTINUE READING
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