Increased VEGF expression correlates with severely reduced cerebral perfusion in glutaric acidemia type I ( GA-1 ) mouse model of diet induced encephalopathy

Abstract

INTRODUCTION: Rapid induction of hypoxia inducible factor 1α (HIF-1α), and its target gene vascular endothelial growth factor (VEGF) has been reported in various animal models of ischemic and hypoxic-ischemic brain injury [1,2]. The proposed neuroprotective role of these genes remains controversial and is a subject of intense investigation [2-4]. Despite… (More)

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