Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

@inproceedings{Kuiper2014IncreasedTA,
  title={Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer},
  author={Caroline Kuiper and Gabi Ursula Dachs and Delwyn G Munn and Margaret Currie and Bridget Robinson and J F Pearson and Margreet C. M. Vissers},
  booktitle={Front. Oncol.},
  year={2014}
}
Ascorbate is a co-factor for the hydroxylases that regulate the transcription factor hypoxia-inducible factor (HIF)-1, which provides cancer cells with a metabolic and survival advantage in the hypoxic environment of solid tumors. However, whether ascorbate affects tumor development is a highly debated issue. We aimed to determine whether tumor ascorbate was associated with HIF-1 activation and patient disease-free survival. In this study, we undertook a retrospective observational analysis of… CONTINUE READING
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