Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

@article{Lim2014IncreasedTD,
  title={Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression},
  author={Mi-ae Lim and Jennifer Lee and Jin-Sil Park and Jooyeon Jhun and Young-Mi Moon and Mi-La Cho and Ho Youn Kim},
  journal={Experimental Gerontology},
  year={2014},
  volume={49},
  pages={55-62}
}
OBJECTIVE Aging has been reported to be associated with changes in immune function. Although frequent infection and the development of malignancy suggest the decline of immune function with aging, changes toward proinflammatory conditions also develop at the same time. Th17 cells are well known CD4(+) T cell subpopulation closely linked to chronic inflammation and autoimmunity. In this study, changes in the Th17 population were investigated to elucidate a possible mechanism for this response… CONTINUE READING

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