Increased TGF-beta and decreased oncogene expression by omega-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice.

@article{Fernandes1994IncreasedTA,
  title={Increased TGF-beta and decreased oncogene expression by omega-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice.},
  author={Gabriel Henrique Barroso Viana Fernandes and C Bysani and Jaya T. Venkatraman and Vishvendra Tomar and Weiming Zhao},
  journal={Journal of immunology},
  year={1994},
  volume={152 12},
  pages={5979-87}
}
This study was designed to investigate the mechanisms by which marine lipids rich in long chain omega-3 fatty acids inhibit autoimmune disease and prolong the survival rate in female (NZB/NZW) F1 (B/W) mice, an animal model for human SLE. Nutritionally adequate semipurified diets containing at 10% either corn oil (CO) or fish oil (FO) were fed from 1 mo of age and were monitored for proteinuria and survival. Proteinuria was detected earlier and became progressively severe in CO-fed mice. The… CONTINUE READING

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