Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis.

@article{Katt2013IncreasedTH,
  title={Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis.},
  author={Janosch Katt and Dorothee Schwinge and Tanja Schoknecht and Alexander M Quaas and Ingo Sobottka and Eike C Burandt and Christoph Becker and Markus F Neurath and Ansgar Wilhelm Lohse and Johannes Herkel and Christoph Schramm},
  journal={Hepatology},
  year={2013},
  volume={58 3},
  pages={1084-93}
}
UNLABELLED T helper (Th)17 cells are important for host defense against bacteria and fungi, but are also involved in the pathogenesis of autoimmune diseases. In primary sclerosing cholangitis (PSC), bile fluid is frequently colonized with pathogens and its strong association with inflammatory bowel disease suggests the contribution of pathogen responses to disease pathogenesis. Interleukin (IL)-17A, the signature cytokine of Th17 cells, was recently described to promote inflammation and… CONTINUE READING