Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice

@inproceedings{Hino2014IncreasedST,
  title={Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice},
  author={Kenta Hino and Atsushi Saito and Rie Asada and Soshi Kanemoto and Kazunori Imaizumi},
  booktitle={PloS one},
  year={2014}
}
OASIS is a basic leucine zipper (bZIP) transmembrane transcription factor that is activated in response to endoplasmic reticulum (ER) stress. Previously, we showed that OASIS regulates final maturation of goblet cells in the large intestine. In the present study, to elucidate the roles of OASIS under pathophysiological conditions, we examined the stress response and inflammatory responses in Oasis deficient (Oasis⁻/⁻) mice exposed to dextran sulfate sodium (DSS) to induce colitis. A significant… CONTINUE READING
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