Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

@article{Hittel2009IncreasedSA,
  title={Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women},
  author={Dustin S. Hittel and Jason R. Berggren and Jane Shearer and Kristen E. Boyle and Joseph A. Houmard},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={30 - 38}
}
OBJECTIVE Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, we characterized the secreted protein profile of muscle cells derived from extremely obese (BMI 48.8 +/- 14.8 kg/m(2); homeostasis model assessment [HOMA] 3.6 +/- 1.0) relative to lean healthy subjects (BMI 25.7 +/- 3.2 kg/m(2); HOMA 0.8 +/- 0.2). RESEARCH DESIGN AND… CONTINUE READING

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Myostatin regulates D.S

  • N Antony, JJ Bass, CD McMahon, MD Mitchell
  • HITTEL AND ASSOCIATES DIABETES,
  • 2009
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