Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population

@article{Chandra2016IncreasedRO,
  title={Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population},
  author={Aditi Chandra and A. Lahiri and Swapan Senapati and B. Basu and Saurabh Ghosh and I. Mukhopadhyay and Akhilesh Behra and Somenath Sarkar and G. Chatterjee and R. Chatterjee},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
HLA-Cw6 is one of the most associated alleles in psoriasis. Recently, Late Cornified Envelop 3 (LCE3) genes were identified as a susceptibility factor for psoriasis. Some population showed epistatic interaction of LCE3 risk variants with HLA-Cw6, while some population failed to show any association. We determined the associations of a 32.2 kb deletion comprising LCE3C-3B genes and three SNPs (rs1886734, rs4112788; rs7516108) at the LCE3 gene cluster among the psoriasis patients in India. All… Expand
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Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis
  • J. Prinz
  • Biology, Medicine
  • Front. Immunol.
  • 2018
TLDR
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