Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

@article{Cowling2012IncreasedRO,
  title={Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine},
  author={Benjamin John Cowling and Vicky J Fang and Hiroshi Nishiura and Kwok-Hung Chan and Sophia. Ng and Dennis Kai Ming Ip and Susan Shui Seng Chiu and G. Leung and J. S. Malik Peiris},
  journal={Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
  year={2012},
  volume={54},
  pages={1778 - 1783}
}
  • B. CowlingV. Fang J. Peiris
  • Published 15 March 2012
  • Medicine
  • Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Key ResultWe randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
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