Increased Risk of Microscopic Colitis With Use of Proton Pump Inhibitors and Non-Steroidal Anti-Inflammatory Drugs

@article{Masclee2015IncreasedRO,
  title={Increased Risk of Microscopic Colitis With Use of Proton Pump Inhibitors and Non-Steroidal Anti-Inflammatory Drugs},
  author={Gwen M C Masclee and Preciosa M. Coloma and Ernst J Kuipers and Miriam C. J. M. Sturkenboom},
  journal={The American Journal of Gastroenterology},
  year={2015},
  volume={110},
  pages={749-759}
}
OBJECTIVES:Microscopic colitis (MC) is characterized by chronic watery diarrhea. Recently, several drugs were reported to increase the risk of MC. However, studies lacked a clear exposure definition, did not address duration relationships, and did not take important biases into account. We estimated the risk of MC during drug use.METHODS:This is a population-based nested case–control study using a Dutch primary care database (1999–2013). Incident MC cases (aged ≥18 years) were matched to… CONTINUE READING
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Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2013

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