Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin.

@article{Zee2009IncreasedRA,
  title={Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin.},
  author={Cynthia L. Von Zee and Michael P Richards and Ping Bu and Jay I Perlman and Evan B. Stubbs},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 6},
  pages={2816-23}
}
PURPOSE This study aimed to determine the effect of lovastatin on Rho G-protein expression and activation in human trabecular meshwork (TM) cells. METHODS Confluent cultures of low-passage (primary) or transformed (GTM3) human TM cells were incubated overnight with vehicle (0.01% ethanol) or activated lovastatin (10 microM). Changes in Rho mRNA, protein content, and activation were quantified by qRT-PCR, immunoblotting, and ELISA, respectively. F-actin organization was determined using Alexa… CONTINUE READING

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