Increased Rho kinase activity in congestive heart failure.

  title={Increased Rho kinase activity in congestive heart failure.},
  author={Maocai Dong and James K. Liao and Fang Fang and Alex Pui-wai Lee and Bryan P. Yan and Ming Liu and Cheuk-Man Yu},
  journal={European journal of heart failure},
  volume={14 9},
AIMS Rho kinases (ROCKs) are the best characterized effectors of the small G-protein RhoA, and play a role in enhanced vasoconstriction in animal models of congestive heart failure (CHF). This study examined if ROCK activity is increased in CHF and how it is associated with the outcome in CHF. METHODS AND RESULTS Patients admitted with CHF (n =178), disease controls (n =31), and normal subjects (n =30) were studied. Baseline ROCK activity was measured by phosphorylation of themyosin-binding… CONTINUE READING


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