Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression.

@article{Kitanaka2002IncreasedRE,
  title={Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression.},
  author={Chifumi Kitanaka and Keisuke Kato and Rieko Ijiri and Kaori Sakurada and Arata Tomiyama and Kohji Noguchi and Yohji Nagashima and Akira Nakagawara and Takashi Momoi and Yasunori Toyoda and Hisato Kigasawa and Toshiji Nishi and Mikako Shirouzu and Shigeyuki Yokoyama and Yukichi Tanaka and Yoshiyuki Kuchino},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 5},
  pages={358-68}
}
BACKGROUND Neuroblastoma undergoes spontaneous regression frequently during its natural course. Although programmed cell death (PCD) has been implicated in this process, accumulating evidence suggests that apoptosis, a form of PCD that is regulated by caspases, may not play a major role. We examined the mechanism(s) of spontaneous regression of neuroblastoma, focusing on the role of Ras, a favorable prognostic marker of neuroblastoma. METHODS Tumor tissues were analyzed by light microscopy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…