Increased RNA polymerase availability directs resources towards growth at the expense of maintenance.

@article{Gummesson2009IncreasedRP,
  title={Increased RNA polymerase availability directs resources towards growth at the expense of maintenance.},
  author={Bertil Gummesson and Lisa U Magnusson and Martin Lovmar and Kristian Kvint and Orjan Persson and Manuel Ballesteros and Anne E Farewell and Thomas Nystr{\"o}m},
  journal={The EMBO journal},
  year={2009},
  volume={28 15},
  pages={2209-19}
}
Nutritionally induced changes in RNA polymerase availability have been hypothesized to be an evolutionary primeval mechanism for regulation of gene expression and several contrasting models have been proposed to explain how such 'passive' regulation might occur. We demonstrate here that ectopically elevating Escherichia coli RNA polymerase (Esigma(70)) levels causes an increased expression and promoter occupancy of ribosomal genes at the expense of stress-defense genes and amino acid… CONTINUE READING
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Bacterial sigma factors

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  • Transcriptional Regulation
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Highly Influential
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