Increased REM sleep in rats selectively bred for cholinergic hyperactivity.

  title={Increased REM sleep in rats selectively bred for cholinergic hyperactivity.},
  author={Priyattam J. Shiromani and David E Overstreet and Darya Levy and Clark A. Goodrich and Scott S. Campbell and J. Christian Gillin},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  volume={1 2},
We have examined the sleep profile of the Flinders Sensitive Line (FSL) of rats, which were selectively bred for supersensitive responsivity to an acetylcholinesterase inhibitor (DFP). These animals have an increased density of muscarinic receptors in striatum and hippocampus and display a number of behavioral and neuroendocrine characteristics that may represent a rodent analogue of clinical depression. A continuous 48-hour sleep EEG recording was obtained. Compared to control rats (the… CONTINUE READING


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