Increased Proliferative Background in Healthy Women with BRCA1/2 Haploinsufficiency Is Associated with High Risk for Breast Cancer

  title={Increased Proliferative Background in Healthy Women with BRCA1/2 Haploinsufficiency Is Associated with High Risk for Breast Cancer},
  author={Benjamin Nisman and Luna Kadouri and Tanir M. Allweis and Bella Maly and Tamar Hamburger and Simon Gronowitz and Tamar Peretz},
  journal={Cancer Epidemiology, Biomarkers \& Prevention},
  pages={2110 - 2115}
Previous studies indicated that BRCA haploinsufficiency was associated with activation of the EGF receptor (EGFR) signaling pathway and increased proliferative activity in mammary epithelial cells of healthy women. We hypothesized that these processes might be reflected in the expression of serologic soluble EGFR (sEGFR) and thymidine kinase 1 (TK1) activity, which signal the initial and final steps of the proliferative pathway, respectively. We found that healthy carriers of BRCA1/2 mutations… 

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Dissertacao de mestrado, Oncobiologia, Departamento de Ciencias Biomedicas e Medicina, Universidade do Algarve, 2015


A presente pesquisa propos-se a avaliar a relacao entre as alteracoes dos proto-oncogenes no câncer de mama, discutindo a mastectomia como medida profilatica, divide opinioes dos especialistas mundialmente.



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