Increased Plasma Citrulline in Mice Marks Diet-Induced Obesity and May Predict the Development of the Metabolic Syndrome

@inproceedings{Sailer2013IncreasedPC,
  title={Increased Plasma Citrulline in Mice Marks Diet-Induced Obesity and May Predict the Development of the Metabolic Syndrome},
  author={Manuela Sailer and Christoph Dahlhoff and Pieter Giesbertz and Mena Katharina Eidens and Nicole J. W. de Wit and Isabel Rubio-Aliaga and Mark Boekschoten and Michael M{\"u}ller and Hannelore Daniel},
  booktitle={PloS one},
  year={2013}
}
  • Manuela Sailer, Christoph Dahlhoff, +6 authors Hannelore Daniel
  • Published in PloS one 2013
  • Chemistry, Medicine
  • In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse models. C57BL/6 mice with diet-induced obesity (DIO) mimic the metabolic impairments of obesity in humans characterized by hyperglycemia, hyperinsulinemia and hepatic triglyceride accumulation. Mice… CONTINUE READING

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