Increased Pathogenicity of a Reassortant 2009 Pandemic H1N1 Influenza Virus Containing an H5N1 Hemagglutinin

@article{Cline2011IncreasedPO,
  title={Increased Pathogenicity of a Reassortant 2009 Pandemic H1N1 Influenza Virus Containing an H5N1 Hemagglutinin},
  author={Troy D. Cline and Erik A. Karlsson and Pamela Freiden and Bradley J. Seufzer and Jerold E. Rehg and Richard J. Webby and Stacey Schultz-Cherry},
  journal={Journal of Virology},
  year={2011},
  volume={85},
  pages={12262 - 12270}
}
ABSTRACT A novel H1N1 influenza virus emerged in 2009 (pH1N1) to become the first influenza pandemic of the 21st century. This virus is now cocirculating with highly pathogenic H5N1 avian influenza viruses in many parts of the world, raising concerns that a reassortment event may lead to highly pathogenic influenza strains with the capacity to infect humans more readily and cause severe disease. To investigate the virulence of pH1N1-H5N1 reassortant viruses, we created pH1N1 (A/California/04… Expand
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