Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat.

@article{Veerasingham2005IncreasedPI,
  title={Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat.},
  author={Shereeni J. Veerasingham and Masanobu Yamazato and Kathleen H. Berecek and J. Michael Wyss and Mohan K. Raizada},
  journal={Circulation research},
  year={2005},
  volume={96 3},
  pages={277-9}
}
Existing evidence led us to hypothesize that increases in p85alpha, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85alpha, p110alpha, and p110delta mRNA was 1.5- to 2-fold higher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) compared with their controls, Wistar Kyoto rats (WKY). The increase in p85alpha/p110delta was attenuated in SHR treated with captopril, an angiotensin (Ang)-converting enzyme… CONTINUE READING

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