Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.

@article{Olson2009IncreasedPA,
  title={Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.},
  author={Lorin E Olson and Philippe Soriano},
  journal={Developmental cell},
  year={2009},
  volume={16 2},
  pages={303-13}
}
PDGF signaling regulates the development of mesenchymal cell types in the embryo and in the adult, but the role of receptor activation in tissue homeostasis has not been investigated. We have generated conditional knockin mice with mutations in PDGFRalpha that drive increased kinase activity under the control of the endogenous PDGFRalpha promoter. In… CONTINUE READING