Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma.

@article{Hsu2010IncreasedPA,
  title={Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma.},
  author={P N Hsu and Tsuey-Ching Yang and Jung-Ta Kao and K M Cheng and Yi-ju Lee and Y Wang and Chin-Tung Hsieh and Cheng-wen Lin and Yi-Ying Wu},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2010},
  volume={30 9},
  pages={1379-86}
}
BACKGROUND/AIMS Hepatitis B infection is a well-known cause of hepatocellular carcinoma (HCC). This study aims to investigate the role that the co-stimulatory molecule CD28 and co-inhibitory molecule programmed death-1 (PD-1) play in compromising the function of tumour-infiltrating lymphocytes (TIL) in hepatitis B virus (HBV)-related HCC. METHODS A total of 45 patients with HBV-related HCC were enrolled during the period February 2008 to March 2010. The immune phenotype and the expression of… CONTINUE READING