Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

@article{Barbour2005IncreasedPI,
  title={Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.},
  author={Linda A Barbour and Shaikh Mizanoor Rahman and Inga Gurevich and Jonathan Leitner and Stephanie J. Fischer and Michael D Roper and Trina A. Knotts and Yen P. Vo and Carrie E McCurdy and Shoshana Yakar and Derek Leroith and C Ronald Kahn and Lewis C. Cantley and Jacob E Friedman and Boris B Draznin},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 45},
  pages={
          37489-94
        }
}
Insulin resistance is a cardinal feature of normal pregnancy and excess growth hormone (GH) states, but its underlying mechanism remains enigmatic. We previously found a significant increase in the p85 regulatory subunit of phosphatidylinositol kinase (PI 3-kinase) and striking decrease in IRS-1-associated PI 3-kinase activity in the skeletal muscle of transgenic animals overexpressing human placental growth hormone. Herein, using transgenic mice bearing deletions in p85alpha, p85beta, or… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 47 CITATIONS

Similar Papers

Loading similar papers…