Increased Osteopontin-Positive Macrophage Expression in Colorectal Cancer Stroma with Synchronous Liver Metastasis

@article{Imano2010IncreasedOM,
  title={Increased Osteopontin-Positive Macrophage Expression in Colorectal Cancer Stroma with Synchronous Liver Metastasis},
  author={Motohiro Imano and Kiyokata Okuno and Tatsuki Itoh and Eizaburo Ishimaru and Takao Satou and Hitoshi Shiozaki},
  journal={World Journal of Surgery},
  year={2010},
  volume={34},
  pages={1930-1936}
}
The macrophages that infiltrate the tumor stroma are termed tumor-associated macrophages (TAMs). TAMs contribute to hematogenous spread of cancer cells especially liver metastasis. Osteopontin (OPN) is also related to tumor metastasis and proliferation of tumors. OPN is mainly expressed in macrophages of stroma other than that of tumor cells. The aim of the present study was to investigate differences in OPN-positive TAMs between cases of colorectal cancer with synchronous liver metastasis and… CONTINUE READING

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