Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects

@inproceedings{Moeller2012IncreasedOB,
  title={Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A2A Antagonist in Cocaine Dependent Subjects},
  author={F. Gerard Moeller and Joel L. Steinberg and Scott D. Lane and Kimberly L. Kjome and Liangsuo Ma and Sergi Ferr{\'e} and Joy M. Schmitz and Charles A. Green and Stephen I. Bandak and Perry F. Renshaw and Larry A. Kramer and Ponnada A. Narayana},
  booktitle={Front. Psychiatry},
  year={2012}
}
BACKGROUND Positron Emission Tomography imaging studies provide evidence of reduced dopamine function in cocaine dependent subjects in the striatum, which is correlated with prefrontal cortical glucose metabolism, particularly in the orbitofrontal cortex. However, whether enhancement of dopamine in the striatum in cocaine dependent subjects would be associated with changes in prefrontal cortical brain activation is unknown. One novel class of medications that enhance dopamine function via… CONTINUE READING

6 Figures & Tables

Topics

Statistics

02040608020142015201620172018
Citations per Year

70 Citations

Semantic Scholar estimates that this publication has 70 citations based on the available data.

See our FAQ for additional information.