Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats.

@article{Nt2010IncreasedOB,
  title={Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats.},
  author={Laszlo G N{\"o}t and Charlye A. Brocks and Laszlo V{\'a}mhidy and Richard B. Marchase and John C Chatham},
  journal={Critical care medicine},
  year={2010},
  volume={38 2},
  pages={562-71}
}
OBJECTIVE To evaluate the effects of O-linked beta-N-acetylglucosamine (O-GlcNAc) levels on survival, inflammation, and organ damage 24 hrs after trauma-hemorrhage. We have previously shown that increasing protein O-GlcNAc levels by different mechanisms reduced inflammatory responses and improved organ function 2 hrs after trauma-hemorrhage. DESIGN Prospective, randomized, controlled study. SETTING Animal research laboratory. SUBJECTS Male, adult Sprague-Dawley rats. INTERVENTIONS… CONTINUE READING
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