Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

@inproceedings{Johnson2017IncreasedNS,
  title={Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis},
  author={Jeffrey R. Johnson and Mahalakshmi Ramadass and Ariela Haimovich and Matthew D. McGeough and Jinzhong Zhang and Hal M. Hoffman and Sergio Daniel Catz},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2017}
}
Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytokines, but the involvement of selective innate immune cells in this process is not fully understood. Neutrophil secretion and the toxic components of their granules are mediators of inflammation… CONTINUE READING