Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

@inproceedings{Johnson2017IncreasedNS,
  title={Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis},
  author={Jeffrey R. Johnson and Mahalakshmi Ramadass and Ariela Haimovich and Matthew D. McGeough and Jinzhong Zhang and Hal M. Hoffman and Sergio Daniel Catz},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2017}
}
Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytokines, but the involvement of selective innate immune cells… CONTINUE READING