Increased Neuronal Excitability, Synaptic Plasticity, and Learning in Aged Kvβ1.1 Knockout Mice

@article{Murphy2004IncreasedNE,
  title={Increased Neuronal Excitability, Synaptic Plasticity, and Learning in Aged Kvβ1.1 Knockout Mice},
  author={Geoffrey G. Murphy and Nikolai B. Fedorov and K Peter Giese and Masuo Ohno and Eugenia L Friedman and Rachel Chen and Alcino J. Silva},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1907-1915}
}
BACKGROUND Advancing age is typically accompanied by deficits in learning and memory. These deficits occur independently of overt pathology and are often considered to be a part of "normal aging." At the neuronal level, normal aging is known to be associated with numerous cellular and molecular changes, which include a pronounced decrease in neuronal excitability and an altered induction in the threshold for synaptic plasticity. Because both of these mechanisms (neuronal excitability and… CONTINUE READING

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