Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.

@article{Glynn2010IncreasedNP,
  title={Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.},
  author={Sharon A Glynn and Brenda J. Boersma and Tiffany H. Dorsey and Ming Yi and Harris G. Yfantis and Lisa A. Ridnour and Damali N. Martin and Christopher H. Switzer and Robert S. Hudson and David A Wink and Dong Ho Lee and Robert M. Stephens and Stefan Ambs},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 11},
  pages={3843-54}
}
Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO) production affect the redox state of cells and can induce protein, lipid, and DNA modifications. To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors. In multivariable survival analysis, increased NOS2 predicted… CONTINUE READING
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